• aaaaaaadjsf [he/him, comrade/them]
    ·
    edit-2
    3 years ago

    30 Suspected cases in Madrid alone, and it looks like sexual transmission is a big driver at the moment, most cases are being reported in gay and bisexual men for now. Could be due to us getting tested and screened for STDs and treating rashes more seriously than the straights though. Too early to draw any conclusions, but I'm not liking the way this is looking...

    As a bi dude I'm not looking forward to this if it spreads...

  • IceWallowCum [he/him]
    ·
    3 years ago

    Deaths blablabla anyway, which pharma company should I be investing in ahead of this?

    • aaaaaaadjsf [he/him, comrade/them]
      ·
      3 years ago

      At least I hope if it spreads a ton, people will take it seriously because it makes you look like a leper and long monkeypox complications include chronic sepsis and bronchopneumonia, along with permanent blindness.

      But if COVID 19 is anything to go by, everyone except China will be pretty fucked until the vaccines and antivirals roll out...

      • panopticon [comrade/them]
        ·
        3 years ago

        Oh, heh, so it wrecks your shit and people are already sick and tired of pandemics and completely done with pandemic protocols? Heh :this-is-fine:

        • aaaaaaadjsf [he/him, comrade/them]
          ·
          edit-2
          3 years ago

          According to the WHO, case fatality rate is 3-6% on average in modern epidemics.

          Also everyone's immune systems just got wrecked by COVID so yeah

        • aaaaaaadjsf [he/him, comrade/them]
          ·
          3 years ago

          The vaccine is gnarly though, Chud antivaxxers are going to freak. Ask people that served in the US military after 9/11 about the smallpox vaccine, it's like over a dozen needles and gives you a big wart. 1 in 10 000 chance of heart inflammation as well.

          Still much, much more preferable to get the vaccine if this spreads.

          • Neckbeard_Prime [they/them,he/him]
            ·
            3 years ago

            I knew a guy who got it and the one big rule was DO NOT SCRATCH THE PUNCTURE SITE. So, naturally, he did, and it spread all over his arm and upper chest. He got written up for it.

            It wasn't "over a dozen needles," either -- just a jabby thing that they stab into your upper arm a few times. It scabs over after a day or two, itches like hell, and then eventually the scab falls off and you're more or less immune to smallpox.

            But yeah, CHUDs are going to flip their shit if vaccinia virus is one of the vaccines that the WHO and CDC say are viable for monkeypox prevention. IT'S RIGHT THERE IN THE NAME!

            • aaaaaaadjsf [he/him, comrade/them]
              ·
              edit-2
              3 years ago

              It seems that the vaccine being ordered is a new smallpox vaccine that uses the single needle intermuscular injection now, and not the stabby Y thing a few times, got approved in 2019.

              • Neckbeard_Prime [they/them,he/him]
                ·
                3 years ago

                What's your source on the eczema part? The NIH says the opposite, at least in the EU:

                https://www.niaid.nih.gov/diseases-conditions/smallpox-vaccine

                People with weakened immune systems or skin conditions, such as atopic dermatitis, or eczema, are at increased risk for serious side effects from Dryvax and Acam2000. NIAID is pursuing the development of new, safer smallpox vaccines that could be used to protect these groups. One candidate developed by the biotechnology company Bavarian Nordic uses a vaccine platform technology known as Modified Vaccinia Ankara – Bavarian Nordic (MVA-BN). NIAID supported early advanced development work for this important vaccine, with initial efforts largely focused on the liquid formulation. NIAID supported preclinical evaluation through Phase II clinical trials of the investigational vaccine. The trials assessed the vaccine in healthy participants, HIV-positive volunteers, and people with atopic dermatitis or a history of atopic dermatitis. These studies evaluated safety, immunogenicity, duration of protection, and route of vaccination.

                Following promising clinical trials results, MVA-BN was transitioned to the Biomedical Advanced Research and Development Authority (BARDA) for advanced development. In 2013, Canada and the European Union approved the vaccine (under the trade names IMVAMUNE and IMVANEX) for use in the general population, including people with weakened immune systems or atopic dermatitis. As of August 2014, 24 million doses were delivered to the U.S. Strategic National Stockpile (SNS) for use among these groups. BARDA also supported large Phase 3 clinical trials of the vaccine. Based on promising data from these studies, the FDA approved MVA-BN (now called JYNNEOS) in September 2019.

                (Bolded emphasis mine)

                • aaaaaaadjsf [he/him, comrade/them]
                  ·
                  edit-2
                  3 years ago

                  That's a much better source, I was trying to decipher the incomprehensible Wikipedia page and the Bavarian Nordic website and PDFs. Which were worded very poorly. Will update my comments, thanks for the correction

            • D3FNC [any]
              ·
              3 years ago

              The military used a trident syringe for smallpox vaccinations, but that would have been pre-1980.

          • TyMan210 [he/him, comrade/them]
            ·
            3 years ago

            From the article about the US ordering the vaccines, it looks like they are ordering the Jynneos vaccine specifically. According to the Wikipedia article at least, Jynneos is administered subcutaneously rather than via scarification, although I haven't read that much into it yet, so it may still cause the same reaction at the injection site. So maybe that will help things, but even in the best case, I know antivaxxers are going to be a huge problem if this starts spreading

              • Neckbeard_Prime [they/them,he/him]
                ·
                3 years ago

                From that Wiki article, Jynneos uses a live but non-replicating (and milder) form of vaccinia, so it's supposed to be safe for people with eczema. The section in the wiki is unclear as all hell and looks like it was copied and pasted from a marketing brochure, but the word salad is just stating that ACAM2000 and Dryvax were unsafe for patients with skin conditions, not that Jynneos is.

              • TyMan210 [he/him, comrade/them]
                ·
                edit-2
                3 years ago

                I hope it can be contained enough that it won't come to mass vaccination, but after covid I'm not super confident in that anymore. The two injections spaced a month apart should be familiar to people from covid at least. This was the source linked to on wikipedia if you happen to want to read into it more (just a warning, it's a PDF). I wish I could be hopeful that proper measures will be taken ( :xi-plz: ). Maybe the fact that the infection is very visible will help clamp down on people claiming it's fake, but again, it's hard to be sure about anything these days

            • Neckbeard_Prime [they/them,he/him]
              ·
              3 years ago

              That's good news for anyone with eczema/psoriasis that wouldn't have been able to get the ACAM2000 version, now that Dryvax is gone.

  • duderium [he/him]
    ·
    3 years ago

    We’ve had first pandemic, yes, but what about second pandemic?

    • D3FNC [any]
      ·
      3 years ago

      Gonna copy my comment from another thread because I really should be getting back to work:

      Nah this is in no way suspicious, and totally unrelated to all these articles that started to appear out of nowhere today accusing Russia of having bioweapons labs working with monkeypox.

      Fuck it, I’m panicking. It’s time to embrace the internal screaming of complete despair that I’ve been trying to ignore since March 2020.

      We have no public health here. If they’re saying they detected a dozen cases in the United States, I guarantee we already have thousands. The same thing is happening with covid right now. STILL. WE ARE STILL DEALING UNSUCCESSFULLY WITH THE PRIOR FUCKING PANDEMIC.

      Here I am stuck between anti science radicals that don’t believe in germ theory, and the supposed experts setting policy in our own government, telling us this is overblown and we shouldn’t worry about it - IT COULD NEVER HAPPEN HERE. This is the worst, and sickest form of deja vu I have ever experienced. WE JUST DID THIS. OH MY GOD

    • Snackuleata [any]
      ·
      3 years ago

      It has precedent though. The first vaccine was infecting someone deliberately with cowpox to build a slight immunity and make smallpox less fatal. Smallpox also doesn't mutate much which is why it was eradicated. Of course I'm still going to treat it like a pandemic but it's not entirely unfounded.

  • bayezid [any]
    cake
    ·
    3 years ago

    Me and the boys in 2006 when we all got poisoned trying to get a dragon scimmy.

  • InevitableSwing [none/use name]
    ·
    3 years ago

    The Wikipedia page - I edited the text to make smaller paragraphs and to create the list...

    Public Health Emergency of International Concern

    A Public Health Emergency of International Concern (PHEIC) is a formal declaration by the World Health Organization (WHO) of "an extraordinary event which is determined to constitute a public health risk to other States through the international spread of disease and to potentially require a coordinated international response".

    [It's] formulated when a situation arises that is "serious, sudden, unusual, or unexpected", which "carries implications for public health beyond the affected state's national border" and "may require immediate international action". Under the 2005 International Health Regulations (IHR), states have a legal duty to respond promptly to a PHEIC.

    The declaration is publicized by an IHR Emergency Committee (EC) of international experts, which was developed following the 2002–2004 SARS outbreak. Since 2009, there have been six PHEIC declarations:

    • the 2009 H1N1 (or swine flu) pandemic

    • the 2014 polio declaration

    • the 2014 outbreak of Ebola in Western Africa

    • the 2015–16 Zika virus epidemic

    • the 2018–20 Kivu Ebola epidemic

    • the ongoing COVID-19 pandemic.

    The recommendations are temporary and require reviews every three months.

    Automatically, SARS, smallpox, wild type poliomyelitis, and any new subtype of human influenza are considered as PHEICs and thus do not require an IHR decision to declare them as such. A PHEIC is not confined to infectious diseases, and may cover an emergency caused by exposure to a chemical agent or radioactive material. It can be seen as an "alarm system", a "call to action" and "last resort" measure.

    • D3FNC [any]
      ·
      3 years ago

      Yeah the United States citizenry, which has never opposed any vaccination program, is definitely going to line right the fuck up to get to one of the vaccines with the most adverse effects in the history of infectious disease.

    • sappho [she/her]
      ·
      3 years ago

      I don't think this is still the case for the newer 2019 Jynneos vaxxes which the USA already ordered. At least, I don't see it mentioned on the package insert with the adverse effects and all.

    • bigboopballs [he/him]
      ·
      3 years ago

      a vaccine where you’re not allowed to scratch your vaccination site (upper arm) and have to be very mindful about it for 3 weeks, otherwise you’d get a beautiful tattoo across your upper arm which resulted as a permanent scar of the vaccine.

      source?