Study Sheds New Light on a Promising Antidepressant - Neuroscience News
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Ketamine's antidepressant effect is a result of the enhancement of Kcnq2 potassium channels in a certain subtype of glutamate-sensitive neurons.

from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/

study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3

The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability

glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters

The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.

an anesthetic and anti-epileptic, chill ass regimen

By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.

boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"