Study Sheds New Light on a Promising Antidepressant - Neuroscience News
neurosciencenews.com
Ketamine's antidepressant effect is a result of the enhancement of Kcnq2 potassium channels in a certain subtype of glutamate-sensitive neurons.

from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/

study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3

The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability

glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters

The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.

an anesthetic and anti-epileptic, chill ass regimen

By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.

boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"

  • GuerrillaMindset [none/use name]
    ·
    2 years ago

    i did ketamine therapy over an extended period of time with intramuscular injections. they even extended me beyond the usual routine, i did a good bit of injections.

    i love drugs and i've done k before but never k-holed like that before. they just shoot you up and off you go in a trip room. they check your vitals and shit and whatever and then you vibe for a few hours and then they kick you out so the next person can come. i joked with my friend that i met god and then a nurse came in to tell me i had 15 minutes to pack up. what a weird experience.

    in the end it did help depression for a few days at a time. in the end what really helped my depression was my material circumstances changing. go figure. it was fun for what it was though and i think it's promising.

    psilocybin mushrooms work a lot better, in my opinion, but it'll probably be a bit until we get to where insurance covers that shit.

    oh, by the way, my insurance is medicaid. if i had private insurance i would have paid $700 per injection. i paid nothing.

    • TheCaconym [any]
      ·
      2 years ago

      it’ll probably be a bit until we get to where insurance covers that shit.

      Until then: everyone that can, grow them. And give them to friends.

    • Omegamint [comrade/them, doe/deer]
      ·
      2 years ago

      I think I'm in the same boat, I've done ketamine and other disso's and the relief feels very temporary. Mushrooms seem far better but I have a much harder time on mushrooms trips than pretty much anything else. I've been thinking about doing mushrooms more regularly and just telling myself that the difficulty with the trip is part of some kind of shamanistic purge because I could really use the relief and I've not had the best time with anti depressants.