I was on a constantly rotating mix of different meds from 2nd grade on until I moved out. I spent a year tapering off one medication at a time (I don't recall what they were at this point). It wasn't bad, though things were generally pretty smooth for me at the time. I wouldn't drop all medications at once, and for me the biggest trouble was sleeping. Most of this can be dealt with by habit forming (i.e. bedtime is 9, not flexible. Don't watch tv or screw with the phone waiting to get sleepy, etc.) Things feel different for quite a while, in a way that is nebulous and pretty hard to describe. Lacking a more useful way to express it, I would say I feel more connected to my life/experiences.

I don't look down on medication, and definitely think that if you need it you should use it but I would personally have a very difficult time going back.