Lots of viruses can set off autoimmune reactions in select populations, but Leonardi thought COVID might have the potential to unsettle the general health of the globe, and even change life expectancy patterns.

Readings on the long-term health impact of the original SARS virus and its cousin MERS also alarmed Leonardi.

These pathogens also disrupted the immune system. MERS, for example, not only infected and killed the cells lining blood walls but T cells as well. Both SARS and MERS could overcome the defences of the immune system, and result in prolonged chronic illness that lasted years.

To Leonardi the ramifications seemed highly significant. It meant that repeated waves of COVID infection might not leave durable or competent memory to fight reinfection or to clear the virus. Repeat infections could get worse over time resulting in more death, organ damage and long-term disability. He started writing letters to school boards and issuing warnings about his conclusions based on his extensive readings.
. . .
“His arguments threatened to undermine the narratives of those people minimizing the pandemic,” Gregory told The Tyee. “If previous infection dampens the immune system and does not strengthen it, it undermines the popular notion that we should let the virus rip.”

Yaneer Bar-Yam, an acclaimed complexity scientist, pandemic expert and director of the World Health Network, agrees. “The reasons Anthony was so broadly attacked was because he undermined the position that once you’ve been infected, you don’t have to worry again.”

Toronto emergency physician Kashif Pirzada has been following Leonardi’s take on COVID and initially didn’t want to believe his predictions on T cells. “But they have stood the test of time and are now being confirmed by multiple lab studies.”

  • MF_BROOM [he/him]
    ·
    2 years ago

    I've heard people argue before that COVID is not the first virus that can cause long-term damage (true), so therefore long COVID isn't a big deal. But that just seems like an inane conclusion to already make because we don't know yet how long COVID will evolve over a longer time frame.

    And even if that were true, it's still stupid to frame it as an apples-to-apples comparison because COVID has evolved to be one of the most contagious diseases in written history. What do you think the odds will be that you are still healthy after getting four annual infections for the next five years?

    • sovietknuckles [they/them]
      ·
      2 years ago

      COVID impairs your immune system similarly to how measles does. People who have had measles can rebuild their immune system in 2-3 years, but that assumes they don't get reinfected with measles again.

      So if you get reinfected with COVID more often than once every 2 years, your immune system just keeps getting worse and worse as long as you stay alive.

    • dat_math [they/them]
      ·
      2 years ago

      Hydrogen bombs aren't the first bombs that obliterate people in a cloud of fire, so probably NBD