Games that, for better or worse, changed the landscape of gaming, invented new genres, had major influences on other games etc.
My shortlist (in no particular order)
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Super Mario 64, basically invented 3D platformers, I mean, Nintendo designed the damn controller around that game
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Resident Evil 4, all 3rd person action games owe a debt to RE4, and for worse probably, set the stage for brown color palate shooters that dominated the subsequent generation
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Doom, the Charlemagne of FPS games, basically every FPS is descended from it
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Fortnite, killed the "loot box" style of predatory monetization in favor of the battle pass model that a ton of other games have switched over to, and was a genuine cultural phenomenon
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Minecraft, the tsunami of survival crafting games of the 2010s all basically emerged from the shadow Minecraft's popularity
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Dune 2, godfather of the RTS genre, no Command and Conquer or Starcraft if Dune 2 isn't a huge success
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World of Warcraft, probably the most influential and well known MMORPG of all time, so many imitators tried to take its crown and failed, and was/is a cultural phenomenon
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Dark Souls, invented the Soulslike genre, launched the career of Hidetaka Miyazaki, and its considered one of the greatest games ever made
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Pokemon Red/Blue, Pokemon is the most profitable media franchise of all time, and Pokemon long served as the flagship of handheld gaming
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Breath of the Wild, I kind of wanted to slot Elden Ring in here because I think ER's influence on the open world genre will be felt for years to come but I think its too early to tell. But BOTW was a genre defining open world game, is on the shortlist for one of the greatest games ever made, and even influenced Elden Ring
I was just thinking about M.U.L.E. the other day and reminiscing about playing it as a little kid and how it likely even informed some of my understanding of economics later on (that's not to say I understand it very well). Groundbreaking game for sure. It was also created by a very talented and pioneering game developer Danielle Bunten Berry who also happened to be a trans woman working in a heavily male dominated industry of 1980s-1990's US.
Edit: Some more tidbits from Berry's wikipedia article:
That's cool I didn't know that.