Yes, though in a mild way. I'm pretty healthy to start but the desk job I've been working for the past year is definitely starting to take its toll. You can get up and stretch, take eye breaks, fill your measly after-work time with a gym routine, but there's no comparison to how active I was when I wasn't working, only working part time, or working outside. I can feel it slowly eroding my physical and especially mental health, and I'm going to need to quit when I save up a bit of money.

Nothing compared to my anxiety about the planet though like /u/emizeko mentioned. Part of the reason I really want to keep my body in proper shape is to be able to handle, for as long as I stay alive, the unimaginable difficulties down the road as we tumble into the abyss.