It's the same story, the first targets of the Nazis were disabled people and trans people after all. US capitalism is in deep crisis and the response is playing out similarly (and differently). People have already made some good points tying patriarchy (including LGBT+ oppression) to social reproduction via uncompensated domestic labour etc. Trans people get the worst of it because they challenge patriarchal structures most directly, and provide an opportunity to mobilize and organize reactionary forces.

There's much more to it, but the most important part is that just because fascism is irrational doesn't mean the directions it takes are incomprehensible. In fact, it's essential for Marxists to understand the similarities and differences between what's going on today and what's happened in the past.