It's personal preference for me, but having played almost every D&D CRPG in the past, from the previous Baldur's Gate entries to Icewind Dale and Neverwinter (and even the old "gold box" AD&D titles such as Pool of Radiance), I've found that I am bored and sick and tired of Illithids whenever they show up. They don't do anything for me and games that have them as a plot point have often been a tiresome slog where I have to get past the part with them in it before I can start having fun again.
For me it's a WOTC/Hasbro property flex they seem to need to keep flexing over and over again because they own it and so I was hoping BG3 had stories and settings and maps that don't feature yet more psionic slavery brainvore fuckery.
That's making me hesitate about my purchase, because I don't know how much of it to expect but the trailers and basic plot pitch on Steam made me worry.
That's what I've done in previous games. When even freaking Icewind Dale wandered into related Underdark cliches, I groaned loud enough to alert my cat. Then I trudged past it and continued playing.
Larian's been pretty good to me.