I use Control-D, both on Android, through DNS over TLS, and at the router level, so that I'm protected from ads and malware, no matter whether I'm on cellular data or on Wi-Fi.

DHCP at the router that gives out these two filtered DNS servers from AdGuard:

• 94.140.14.14
• 94.140.15.15

https://adguard-dns.io/en/blog/adguard-dns-new-addresses.html

When using the network-wide VPN configuration of my firewall, I also use OPNSense to enforce that all devices connect to my self-hosted Pi-Hole, including redirecting DNS packets that are sent to DNS servers other than my Pi-Hole IP. There's a pretty cool guide for this: https://forum.opnsense.org/index.php?topic=9245.0

When running a VPN client on a device, I just use the VPN to manage DNS settings.
Both Mullvad and IVPN have very solid DNS settings within their desktop clients. Proton VPN unfortunately lacks behind in this regard. That's why I never use any Proton VPN clients on desktop, and rely on OPNSense, if I want to use Proton.

/etc/unwind.conf

block list "/var/db/unwind_blocklist"
forwarder { X.X.X.X port X DoT X.X.X.X port X DoT }
preference { DoT }

unwind_blocklist is generated with this script I wrote:

#!/bin/sh
# Blocklists for unwind(8)

blocklist=/var/db/unwind_blocklist
[ ! -f $blocklist ] && \
        (umask 117; touch $blocklist && chgrp _unwind $blocklist)

{
        ftp -V -o - \
            https://blocklistproject.github.io/Lists/alt-version/everything-nl.txt \
            http://winhelp2002.mvps.org/hosts.txt \
            http://sysctl.org/cameleon/hosts \
            https://s3.amazonaws.com/lists.disconnect.me/simple_tracking.txt \
            https://s3.amazonaws.com/lists.disconnect.me/simple_ad.txt \
            https://raw.githubusercontent.com/Perflyst/PiHoleBlocklist/master/android-tracking.txt
        echo twitter.com
        echo www.twitter.com
        echo www.x.com
        echo x.com
        echo facebook.com
        echo www.facebook.com
} | awk -safe '
        !/^M|#|(^|\.)[[:blank:]]*$|^definitely_not_porn$/ {       
                if ($1 ~ /127\.0\.0\.1|0\.0\.0\.0/) {
                        $0 = $2
                }
                if ($0 ~ /[[:upper:]]/) {
                        print tolower($0)
                } else {
                        print $0
                }
        }
' | sort -u >$blocklist
rcctl restart unwind

Regenerates occasionally with cron.

DNS is handled by my rpi that's running pi-hole and wireguard. It has static entries for quad nine and it's secondaries. Router (generic rax10 Netgear, nothing fancy, and it's not obnoxious like the nighthawks) DNS points to rpi.

So any device, set with dhcp, will use that. One day I'll have a opnsense or similar box to go even further.

I use several providers as upstream for Adguard Home where my blocklists, regex blocks and DNS rewrites are. Via DNS-over-TLS URL for Android phones or DHCP with the IP of the DNS-server they get directed to it.

https://github.com/DNSCrypt/dnscrypt-proxy ina router

I use NextDNS. I use it network wide on my home internet and also have it installed on all my devices.

I just use Mullvad VPN's default DNS servers (with ad blocking, tracker blocking, and malware blocking)

TrackerControl on android, pihole at home.