Yes, and no

Mr. Freeze started off wanting to avenge his wife's death at the hands of one Ferris Boyle

Then it turned out she wasn't dead, just being held hostage by a fake Walt Disney guy

Then the events of Batman and Robin: Sub-Zero happen and Freeze's wife gets some organ transplants and is fine

Then we see the reason why Mr. Freeze didn't go off to live with his wife

His condition was deteriorating and before they could stabilize it, he's left as a head in a jar, so he goes all Final Fantasy villain and wants to destroy everything because his life is fucked

Batman stops him, he spends 50 years in a box, Derek Powers has him cloned into a new body which also begins to deteriorate, Freeze escapes before they can kill him and examine his organs, comes back with new Freeze suit, tries to cause a nuclear reactor to meltdown, he ends up sacrificing himself to help save Batman when Derek Powers tries to kill them both with his new radiation powers

And yeah, that's Mr. Freeze from the Batman: The Animated Series

The comics get weirder