On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being "central" enough to be used as a "North" (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your "North" be?
Center of gravity of the galactic cluster/supercluster
So your momma?
*removed externally hosted image*
We already have one. Its Mecca, and all the aliens are Muslim.
(putting my shitposts with the other shitposts so they don't bother)
Works very well until you're moving between superclusters, at which point the universe becomes homogeneous (as far as is known). At that point you probably just need to set an arbitrary origin for your system of coordinates.