I qualified for financial help with one of those places that advertise on social media (Joyous, if you know it), and I've got enough to buy myself the first month of pills.

Curious as to if anyone has had experience with it. On paper it sounds like it would be great for me, but my ma is scared of it cause apparently there are horror stories going around in the news. Way I figure it, if it doesn't help, at least I get drugs.

  • Sulvor [he/him, undecided]M
    ·
    5 days ago

    First month of pills? I thought esketamine was only approved as a nasal spray.

    There’s a phase 2 trial from this summer, but idk if it’s been approved yet.

    https://www.nature.com/articles/s41591-024-03063-x

    Someone correct me if I’m wrong but they may be enrolling you in a clinical trial, for which you should be paid.

    • JustSo [she/her, any]
      ·
      5 days ago

      Someone correct me if I’m wrong but they may be enrolling you in a clinical trial, for which you should be paid.

      I think they're doing legal loophole fuckery with the blessing of a corrupt or lazy physician. I've seen it with other substances and it can be a trainwreck for legitimate research progress. I'm actually kind of alarmed to be hearing about this sort of operation.

      • Sulvor [he/him, undecided]M
        ·
        5 days ago

        If it’s not a clinical trial idk how they’re doing this, legally speaking. I do recreational drugs, but this ain’t that, and there’s procedures and laws to follow. Sometimes those procedures are exploited by companies for profit, but at their base they are there to protect the public from those same companies.

        • JustSo [she/her, any]
          ·
          4 days ago

          FYI, a friend shared this, it links to actual papers. It sounds like the product being offered here. I haven't read enough yet to know if any of this has gone past clinical trial stages, but you are dead right that Corgi is probably entitled to receive compensation if this is a trial. Could that be the loophole and they're just counting on ignorance or some corporate / marketing construct to launder the trial / fast-track putting the formulation onto the market for a purely profit driven motive?

          https://www.osmind.org/blog/sublingual-ketamine-troches-for-home-use-an-evidence-based-introduction-part-1

          Friend also suggested that some of the links may be inaccurate, so I suppose further digging would be required to match paper titles with their papers in the usual databases. Obviously "osmind.org" doesn't hit with a lot of authority.

          • Sulvor [he/him, undecided]M
            ·
            4 days ago

            Yeah they do quote a fair amount of studies in there but it’s late for me to scan several studies. I posted this earlier but this is probably the highest quality trial that is working towards approval for oral ketamine for depression

            https://www.nature.com/articles/s41591-024-03063-x

            In this phase 2 multicenter clinical trial, male and female adult patients with TRD and Montgomery–Asberg Depression Rating Scale (MADRS) scores ≥20 received open-label R-107 tablets 120 mg per day for 5 days and were assessed on day 8 (enrichment phase). On day 8, responders (MADRS scores ≤12 and reduction ≥50%) were randomized on a 1:1:1:1:1 basis to receive double-blind R-107 doses of 30, 60, 120 or 180 mg, or placebo, twice weekly for a further 12 weeks.

            Not even close to daily dosing, as has been shown previously with esketamine (monthly) to be far more effective.

            • JustSo [she/her, any]
              ·
              4 days ago

              Yup. I think the concern displayed by all in this thread is valid and appropriate given what's been properly studied.

              Appreciate the summary/abstract. I'm getting into the NYE spirit right now and have been posting on and off all day so my capacity to read studies and grok them is diminished.

        • JustSo [she/her, any]
          ·
          4 days ago

          I'm sure we'll be reading about the details in the alternative press and then mainstream news within the next couple of years after a bunch of burnout casualties result from this.