I qualified for financial help with one of those places that advertise on social media (Joyous, if you know it), and I've got enough to buy myself the first month of pills.

Curious as to if anyone has had experience with it. On paper it sounds like it would be great for me, but my ma is scared of it cause apparently there are horror stories going around in the news. Way I figure it, if it doesn't help, at least I get drugs.

  • JustSo [she/her, any]
    ·
    6 days ago

    Aight I've just hit up my friendly neighbourhood biochemistry dropout, I've been looping them in on the subjects coming up in this thread, since this lozenge / sublingual dose ketamine was news to them.

    They had just finished reading a paper where the ketamine was trialed in conjunction with Zoloft/sertraline. It seems like things get more complicated with the more exotic compounds like 3-HO and MXE. Definitely check with a prescribing physician and do further research, but my experience might be tainted from a period of time when the market was not a reliable source for pure ketamine and so we had to stay on the safe side.

    Edit: Sorry, to put that more clearly- proper medical grade ketamine may in fact be safe to use in conjunction with some anti-depressants.

    Edit #2:

    yeah it's 3-MeO-PCP (and OG pcp) that has action at the SERT receptor enough that you might not wanna combine it with SSRI's

    This is (apparently) not the case with ketamine. I may have been too hasty with that warning earlier.

    • Sulvor [he/him, undecided]M
      ·
      6 days ago

      Safe does not mean effective at treating depression. I personally cannot imagine daily ketamine use to help depression, similar to how daily benzodiazepines are no longer used for depression or PTSD, as studies have shown they are just as, if not more likely, to worsen symptoms.

      • JustSo [she/her, any]
        ·
        6 days ago

        Correct they should be used as an adjunct therapy to buy the patient temporary relief and the mental space to move forward while actively working to form new sustainable behavior patterns and learning skills to cope with intrusive thoughts and triggering situations.

        I believe this is also true of most SSRIs but that will probably be a controversial opinion, since those drugs do not work on the correct timescales to be used effectively for that sort of treatment given the ramp-up and taper-off requirements and general roulette wheel of finding one that "works" for the patient.

        Edit: And this is really the crux of why the service Corgi has found is highly suspicious. Without offering therapy, just meds, they are not on some well meaning hippocratic oath keeping mission. It's a loophole exploit.