So I had a whole reply typed up, but the site is acting up.
I'll just say that, in the lore, Weyland is a successful Anglo-capitalist company. Great innovations that make life better for everyone, and makes a killing in the process, but still goes bankrupt. It's then bought by Yutani, a rising Japanese conglomerate. Weyland-Yutani then goes on to swindle and basically subserviate the US government. I see that as an Orientalist trope at the root of the cyberpunk genre (not the aesthetic).
So, yes. Alien did latch on to Orientalist trends in contemporary sci-fi. However, Weyland-Yutani is presented as basically Anglo-American in the franchise and it delivers a strong anticapitalist message without ever demonizing Asians. Come to think of it, I don't recall any Asians in the movies... Oh well. I'd say it's disputable. I would call it Orientalist, though derived from cliche instead of racism. I understand if other's don't think that bit of lore makes it Orientalist.
Yes, I suppose that's correct. It's after his death that the Yutani corporation buys Weyland Corp.