Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
www.ncbi.nlm.nih.gov
The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently ...

A cohort of human patients previously taking CBD had significantly lower SARSCoV-2 infection incidence of up to an order of magnitude relative to matched pairs or the general population

An order of magnitude is a SIGNIFICANT reduction yall like wow

CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after viral entry, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD inhibits SARS-CoV-2 replication in part by up-regulating the host IRE1α RNase endoplasmic reticulum (ER) stress response and interferon signaling pathways. In matched groups of human patients from the National COVID Cohort Collaborative, CBD (100 mg/ml oral solution per medical records) had a significant negative association with positive SARS-CoV-2 tests. This study highlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials.

Link is an updated study 1 from 2022, the link in the post is the original study from 2021

They immediately go on to caution against using CBD against covid but COME ON Y'ALL. Are you readin' what I'm readin'?

CBD is, to my understanding, pretty fucking benign and almost impossible to like OD on. IMO there's no reason outside of cost NOT to be juiced to the gills on CBD all the time, at least if you're worried about covid

Note: the studies note that THC actually inhibits these effects, so you can't just get high on the reefer, you need actual CBD. It also notes various methods of delivery might be more or less biologically active as CBD is very hydrophobic and easily forms clumps that get broken down in the liver

Anyway once again I am left thinking "why does nobody else talk about this"

It weirds me out, honestly, like, with all the other snake oil bullshit attributed to CBD, why not this too? And with people desperate to try literally anything to not die of covid, to the point they drink horse dewormer and their intestines fall out........ why hasn't this gotten any attention? It's like some kind of SCP-####, a blankness in people's attention. This relatively cheap, ubiquitous, non toxic drug could help cut down both covid transmission and severity of infections but nobody talks about doing CBD as a covid prophylactic except for me being a crank about it!

  • Bnova [he/him]
    ·
    28 days ago

    I'm not really familiar with cbd dosages but they were doing 100mg/ml doses, which seems quite high. So if you're planning on using it for prevention consider that.

    • Black_Mald_Futures [any]
      ·
      28 days ago

      Yeah idk what that really means though because that's just telling you what the concentration of whatever without telling you how much was administered? Like if it's 100mg/ml but they only took 1ml, that's 100mg of cbd

      • Bnova [he/him]
        ·
        28 days ago

        I looked at the supplemental, where the methods are, and it would appear that the most effective dose (highest they used) was 10 micro liters, which would be 1/5th of a drop from a tincture. If this is correct then you could get away with a single drop from a lower concentration and be fine.

        • Black_Mald_Futures [any]
          ·
          28 days ago

          we should put it in the water, like fluoride, i bet it'd cut infections to some degree

          maybe help me sleep a little better too 😔