Zeus became addicted to consuming souls after killing Cronus. He industrialized the consumption of human souls. The gods dress up this horrifying fact with bread & circuses and lies about how the system works.

Zeus hears a prophecy that his reign will end and starts acting out. He starts killing humans in order to re-establish his dominance. Humans start to rebel against the gods.

One of the main characters (Caeneus) is an Amazonian who was kicked out after transitioning from girl to boy. So the show does little things like that which reflect the original mythology but puts it in modern terms.

Orpheus is Ed Sheeran. Prometheus and Charon are lovers. The underworld is a labor camp for people who weren't buried with their coins.