It's pretty much about how the end of history (and the last man) was dumb and wrong and libs are fools to think that centrist "ideology" is the be-all end-all. One of the coolest points in the video, I think, is pointing out that Alpha Centauri has a kind of default "good guy" faction, the UN Peacekeepers, who are supposed to represent the neolib status quo. BUT whereas that faction would usually be presented as such, instead it is presented as just one of many ideologies, in no way superior, in a way that clashes pretty seriously with the 90's consensus.

In short, Fukuyama can get fucked.