Wondering what Hexbear’s thoughts on this are. Seems they’ll be out next year too.
I feel like they’re overhyped. Iirc both China an India have nasal vaccines, and they have yet to achieve sterilizing immunity. What do you think? Also, do you think next year is too soon a deadline for these vaccines?
Live attenuated vaccine (live organisms engineered to reduce their virulence) almost always elicit a stronger response than just protein vaccination (including mRNA-induced protein expression), as it mimics natural infection. One concern about live attenuated vaccine is their safety profile, and not knowing what the attenuated viruses can do because they are still live viruses after all.
However natural infection didn’t protect those with prior infection from Omicron, nor will it protect them from the more recent JN.1 and EG5.1 circulating variants that are already deviating very far from the initial strains, to the point where our immune system can no longer recognize.