Here are some that I can think of:
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Michael Richards- used the n-word multiple times in response to black hecklers during a stand-up performance.
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Roseanne Barr- said Valerie Jarrett, who is partially black, looked like a Planet of the Apes character.
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Gina Carano- compared Joe Biden's policies as President to the Holocaust.
Even then, Carano will be working for The Daily Wire and Barr was doing a stand-up tour prior to the coronavirus pandemic. Also, Richards has made or still does make a lot of money off of Seinfeld and probably could have had a career like Jason Alexander (making the rounds as a television guest star), if he wanted.
dunno if internet people count, but adam koebel got actually cancelled for gming a sexual assault scene, without warning, where the person who played the character on the recieving end of it was an irl sa survivor, in front of thousands of people on twitch, then laughed about it in the aftershow
this was a guy who was one of the figureheads of the make rpgs inclusive and socially conscious movement
(rightly) killed his career completely
God I forgot about that. Absolutely fucking gross
Bruh