Here are some that I can think of:
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Michael Richards- used the n-word multiple times in response to black hecklers during a stand-up performance.
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Roseanne Barr- said Valerie Jarrett, who is partially black, looked like a Planet of the Apes character.
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Gina Carano- compared Joe Biden's policies as President to the Holocaust.
Even then, Carano will be working for The Daily Wire and Barr was doing a stand-up tour prior to the coronavirus pandemic. Also, Richards has made or still does make a lot of money off of Seinfeld and probably could have had a career like Jason Alexander (making the rounds as a television guest star), if he wanted.
I agree with Kaepernick.
However, with Griffin, that made her into a hero amongst the resistance crowd. In the long run, it probably helped her career.
The real hit to Griffins career was losing the battle with Andy Cohen for Anderson Cooper’s friendship.