Something that I have been trying to better understand the impact of when it comes to repeated boosters is the concept of original antigenic sin. In some cases it seems that if you've been vaccinated against one strain, and then challenged with a slightly different one, the immune system produces an antibody response that is more tailored to the original strain and a weaker response to the new variant.
the mRNA vaccines have much more substantial side effects
Do they? This doesn’t match what I‘ve heard and read nor does it match my personal experience. In fact, the people I know who got vaccines that weren’t mRNA vaccines had much stronger reactions than those who got the mRNA versions.
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Something that I have been trying to better understand the impact of when it comes to repeated boosters is the concept of original antigenic sin. In some cases it seems that if you've been vaccinated against one strain, and then challenged with a slightly different one, the immune system produces an antibody response that is more tailored to the original strain and a weaker response to the new variant.
Do they? This doesn’t match what I‘ve heard and read nor does it match my personal experience. In fact, the people I know who got vaccines that weren’t mRNA vaccines had much stronger reactions than those who got the mRNA versions.