I'm already hearing about protests and actions being planned in my area, and some talk about how this summer's reaction to it could be similar to or bigger than 2020. Personally I don't know. The 2020 uprisings were global because white supremacy and police brutality are global, but I feel like the US is so particularly backwards regarding abortion that you'd have a hard time getting protests going in other countries where the right to choose is more well-protected.
Abortion is already effectively illegal in around a dozen states and they're the ones most likely to ban it entirely. That should have already prompted riots, but so far hasn't (that I'm aware of).
Flipping Roe would mean it becomes illegal or highly restricted in another dozen or so states I'd guess. I really don't know what might happen. I can't see a large demographic migration because housing costs are too high.
I could easily see some odd thing we don't expect to catalyze another series of riots all over the country, but I have no idea when or how