This game just came out last week, I think some here might enjoy it.
It has very simple TTRPG-inspired dice mechanics and the story has me hooked
Roleplaying in the ruins of interplanetary capitalism. Live the life of an escaped worker, washed-up on a lawless station at the edge of an interstellar society. Inspired by the flexibility and freedom of TTRPGs, explore the station, choose your friends, escape your past and change your future.
You play as someone whose consciousness has been bought and transferred into a synthetic body to perform labor in deep space, but you have been waylaid at a hub station while being shuttled to your assignment. This could be your chance to escape...
A DRM free copy is available on GOG-games.com
Its 10% off on Steam until May 12th if you want to support the dev
Is it just the box being on the right side? Shadowrun Returns had it back in 2013. I guess it's just an effective design for fitting both the dialogue and some kind of expressive character portrait on the screen, which is useful in isometric RPGs where you can't really see characters' faces in normal gameplay