Why wouldn't you right? You're passing up so much loot if you don't!
But yeah, I'm an obsessive packrat in those games, pick up anything not nailed down/not considered stealing. So you know I write down the locations of any locked stuff beyond my level to go back and get it later, even if it's just a lunchbox or some shit lol.
I just rock Boon and Ed-e so I don't actually have to fight anything.
You come out of dead money with so much cash you can just give boon all the anti mat rifle ammo he can ever use. Once you know the timing for the palm stun the game is ez mode. That timing is also incredibly easy. Superheated saturnite fists is all you need for the whole game.
Now I wanna play new Vegas again. Time to spend 12 hours modding :sadness-abysmal: