Study Sheds New Light on a Promising Antidepressant - Neuroscience News
neurosciencenews.com
Ketamine's antidepressant effect is a result of the enhancement of Kcnq2 potassium channels in a certain subtype of glutamate-sensitive neurons.

from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/

study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3

The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability

glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters

The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.

an anesthetic and anti-epileptic, chill ass regimen

By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.

boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"

  • Dingdangdog [he/him,comrade/them]
    ·
    2 years ago

    Prozac fucked me up. It taught my body how to have panic attacks while asleep. Took it for anxiety and it just gave my system a new way to fuck with me.

    • ClimateChangeAnxiety [he/him, they/them]
      ·
      2 years ago

      The only thing I really have felt from it is a complete lack of impulse control, which has pushed my alcoholism to 11. Also I sweat like a pig at anything above 74 degrees.

      Edit: The best thing I was ever on was Wellbutrin + Buspar + Olanzipine but it wasn’t good enough and had really unpleasant side effects so I’ve been trying new things but nothing had worked and they denied me ketamine

      • JoeBrandonOfficial [none/use name]
        ·
        2 years ago

        If fent wasn't literally everywhere then I would say you should just go find some ket, I guess you could get a fantasy test if you wanted, I think ket tends to be roughly 10-15 dollars a point, you could probably pick up a gram for like 80 or 90 though

        • dismal [they/them, undecided]
          ·
          2 years ago

          i tried to resist the urge to post this but if you know where/how to get it it should really only be costing 30 a g max for the good stuff. if anyone is charging that much theyre ripping you off or being ripped off themselves

          • JoeBrandonOfficial [none/use name]
            ·
            2 years ago

            I never bought a gram of ket, I had a guy I would get a point for 10 dollars from and he gave me decent deals on lots of stuff back in the day. Usually pretty high quality too. I just extrapolated it out to the general, "10 dollars a point, get 2 free points If you buy a gram" that you see with other drugs like this (LSD, MDMA mostly)

          • JoeBrandonOfficial [none/use name]
            ·
            2 years ago

            I did it a long time ago, I would say if you want to go that route, at least have a close friend there sober to monitor you and to get things you need, and definitely make sure you test it to make sure it's not Fentanyl and that it's real ketamine