German man got 217 COVID shots over 29 months—here’s how it went

It conflicts with concerns of repeat boosters, but authors warn against hypervaccination.

A 62-year-old man in Germany decided to get 217 COVID-19 vaccinations over the course of 29 months —for "private reasons." But, somewhat surprisingly, he doesn't seem to have suffered any ill effects from the excessive immunization, particularly weaker immune responses, according to a newly published case study in The Lancet Infectious Diseases.

The case is just one person, of course, so the findings can't be extrapolated to the general population. But, they conflict with a widely held concern among researchers that such overexposure to vaccination could lead to weaker immune responses. Some experts have raised this concern in discussions over how frequently people should get COVID-19 booster doses.

In cases of chronic exposure to a disease-causing germ, "there is an indication that certain types of immune cells, known as T-cells, then become fatigued, leading to them releasing fewer pro-inflammatory messenger substances," according to co-lead study author Kilian Schober from the Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene. This, along with other effects, can lead to "immune tolerance" that leads to weaker responses that are less effective at fighting off a pathogen, Schober explained in a news release.

My guess is that his t-cells are fine because he's had constant antibodies so the t-cells haven't had to mop up anything, and also it's not a live virus. If you are living life like it's pre-covid times, you're most certainly being constantly exposed to covid anyway.

If you aren't over 65, or immunocompromised, and you find a way to get two vaccines a year, you'll probably be fine. People doing this have had mixed results in regards to how the 1-per year recommendation is being enforced and the CDC official covid advice is now "fuck it, do whatever, yolo", so why not?

If you got an MRNA in the fall, maybe try novavax for less side effects and a slightly different spectrum of protection.