Imagine you live in the US and you have dual citizenship: American/Canadian. You have a job that allows travel. Considering the Christofascism that's coming...
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When would you move to Canada?
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If you stayed in the US - when might you realize you waited far too long and you had a "Oh, fuck - I'm the frog" moment?
I want to stay in the US and I live in a super-blue county in a blue state. But I don't want to become the frog. I have such dual citizenship and moving is doable for me provided I plan as far ahead as possible. I don't expect Canada to be nirvana but I fear the worst for the US.
In terms of self-preservation: immediately if there are no other factors keeping you in the US.
When the Brownshirts are organized and patrolling and nobody is stopping them.
With that said, there's still time to do organizing work before the status quo shifts substantially. That status quo is already bad, so I understand people wanting to leave, though.
At this point I think having sympathetic comrades outside of the US is at least as important as having them in the US. We need to start thinking about escape routes for the most vulnerable.