It's a thing in US drugs to add Acetaminophen to drugs specifically to make them toxic and liver destroying, specifically so if people try to get high they're die painfully. They do it famously with tylenol three, which is codeine with acetaminophen. The acetaminophen is only there to make it poisonous.
That's not true, Tylenol 3 is a medicine and it's prescribed to treat certain conditions. The opiate component exists to trick your cns into believing that the pain isn't there and the acetaminophen functions to prevent the action of prostaglandin, reducing inflammatory response. If you want to get high, by all means get high, but it's patently false to say that there are additives in pain relievers to make it poisonous.
If that's true, why not formulate with a safer prostaglandin inhibitor like Ibuprofen instead of acetaminophen where even a 2x dose can do lasting liver harm?
Because Tylenol 3 has fda approval and ibuprofen with codeine does not. There is ibuprofen with codeine in the UK. The motive is cost savings, pure and simple.
Acetaminophen is good stuff, I took it when I had serious 40°C fever some time ago (not COVID) and got better almost instantly
It's always a bit reckless to put several active ingredients into medicine imo
It's a thing in US drugs to add Acetaminophen to drugs specifically to make them toxic and liver destroying, specifically so if people try to get high they're die painfully. They do it famously with tylenol three, which is codeine with acetaminophen. The acetaminophen is only there to make it poisonous.
That's not true, Tylenol 3 is a medicine and it's prescribed to treat certain conditions. The opiate component exists to trick your cns into believing that the pain isn't there and the acetaminophen functions to prevent the action of prostaglandin, reducing inflammatory response. If you want to get high, by all means get high, but it's patently false to say that there are additives in pain relievers to make it poisonous.
If that's true, why not formulate with a safer prostaglandin inhibitor like Ibuprofen instead of acetaminophen where even a 2x dose can do lasting liver harm?
Because Tylenol 3 has fda approval and ibuprofen with codeine does not. There is ibuprofen with codeine in the UK. The motive is cost savings, pure and simple.
Interesting...
Are OTC formulations subject to the same FDA standards as prescription? Like does Vicks have to seek separate FDA approval for every NyQuil?
No, so long as the components adhere to an already approved OTC monograph each new formulation doesn't require a separate approval.
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