Hey max how about you do some actual journalism and find out what policies the Russians and Chinese used other than vaccines to handle the pandemic so well and shine a light on that instead of antivax quackery.
That "antivax quackery" is about to become mainstream in the West. Max's joke isn't well written, though I do think there's potential. It just doesn't have the right phraseology.
But the truth of the COVID-19 vaccine programme is that it's a colossal failure and fuck-up and regulators in many countries were asleep at the wheel. I've written a lot about it here and it's been several months since anything got removed so I have to believe people are coming around to these facts. For reference I'm a clinical data scientist & AI developer for a consulting company which also produces the software for conducting clinical trials, both the patient outcome assessment and depot/site drug resupply. I worked with trial data for many COVID medical products (Pfizer, Regeneron, BMS, Inovio, Janssen among others).
In short, the virus mutates too quickly to be neutralized by current vaccines and their spike protein subunit-based platforms. Doesn't matter if it's DNA, RNA, mRNA, chemically conjugated tetanus toxoid (though all of the Finlay Institute in Havana vaccines are somehow less injurious but efficacy is about the same), adenoviral vector, whatever... It's still a good idea for older folks and severely at-risk individuals. However, I can't find a single metric which indicates the "reduction" in symptoms that CDC used to continue recommending the COVID-19 vaccines was worth the tradeoffs. We basically imprinted half of younger people with spike protein subunit antibodies for the original version of the virus isolated from a sample taken in Wuhan, more than a year after this strain had effectively already stopped circulating in human populations. Immune system memory is really well understood and we do not have the technology to "update" someone's immune response. Mainstream media orgs are starting to let the mask slip with regards to imprinting, or "original antigenic sin" depending on how Biblical you like your immunology terms. None of the FDA-approved COVID shots have been pulled from the market despite their entire biologics licensing being for PREVENTION of COVID-19 - something it never did, even in the clinical trials. FDA knows this stuff or very well should have, everyone in industry knows this stuff. It's why Dengue, RSV, and other coronavirus (MERS/SARS), etc vaccines have always failed in trials and been pulled from the market when they did slip through: shit mutates, memory T cells and immune system imprinting are (almost) forever.
This is a looming disaster for Democrats, hence Biden's pleading with the press to stop talking about it so he can try to pass the buck to Trump for Operation Warp Speed and tie the vaccine programme around his neck despite their equally disastrous handling of everything (OSHA mandates, FDA approvals, abuse of the EUA terms releasing manufacturers from liability well after the marketability approvals).
I guess all of this is over my head. I can understand vaccination being ineffective as the virus outpaces the innoculation. But I'm not really clear what "original antigenic sin" is or why it would be a problem.
Is this simply a complaint that these vaccines don't mitigate risk? Or are you suggesting some kind of long term problem with innoculation?
Hey max how about you do some actual journalism and find out what policies the Russians and Chinese used other than vaccines to handle the pandemic so well and shine a light on that instead of antivax quackery.
Uh... Russia did not handle the pandemic well.
That "antivax quackery" is about to become mainstream in the West. Max's joke isn't well written, though I do think there's potential. It just doesn't have the right phraseology.
But the truth of the COVID-19 vaccine programme is that it's a colossal failure and fuck-up and regulators in many countries were asleep at the wheel. I've written a lot about it here and it's been several months since anything got removed so I have to believe people are coming around to these facts. For reference I'm a clinical data scientist & AI developer for a consulting company which also produces the software for conducting clinical trials, both the patient outcome assessment and depot/site drug resupply. I worked with trial data for many COVID medical products (Pfizer, Regeneron, BMS, Inovio, Janssen among others).
In short, the virus mutates too quickly to be neutralized by current vaccines and their spike protein subunit-based platforms. Doesn't matter if it's DNA, RNA, mRNA, chemically conjugated tetanus toxoid (though all of the Finlay Institute in Havana vaccines are somehow less injurious but efficacy is about the same), adenoviral vector, whatever... It's still a good idea for older folks and severely at-risk individuals. However, I can't find a single metric which indicates the "reduction" in symptoms that CDC used to continue recommending the COVID-19 vaccines was worth the tradeoffs. We basically imprinted half of younger people with spike protein subunit antibodies for the original version of the virus isolated from a sample taken in Wuhan, more than a year after this strain had effectively already stopped circulating in human populations. Immune system memory is really well understood and we do not have the technology to "update" someone's immune response. Mainstream media orgs are starting to let the mask slip with regards to imprinting, or "original antigenic sin" depending on how Biblical you like your immunology terms. None of the FDA-approved COVID shots have been pulled from the market despite their entire biologics licensing being for PREVENTION of COVID-19 - something it never did, even in the clinical trials. FDA knows this stuff or very well should have, everyone in industry knows this stuff. It's why Dengue, RSV, and other coronavirus (MERS/SARS), etc vaccines have always failed in trials and been pulled from the market when they did slip through: shit mutates, memory T cells and immune system imprinting are (almost) forever.
This is a looming disaster for Democrats, hence Biden's pleading with the press to stop talking about it so he can try to pass the buck to Trump for Operation Warp Speed and tie the vaccine programme around his neck despite their equally disastrous handling of everything (OSHA mandates, FDA approvals, abuse of the EUA terms releasing manufacturers from liability well after the marketability approvals).
Never go outside again? Way ahead of you.
I guess all of this is over my head. I can understand vaccination being ineffective as the virus outpaces the innoculation. But I'm not really clear what "original antigenic sin" is or why it would be a problem.
Is this simply a complaint that these vaccines don't mitigate risk? Or are you suggesting some kind of long term problem with innoculation?