Recently it's gotten a fair bit better. In the latest edition of the Cyberpunk TTRPG rules, only cybernetics that would give you superhuman abilities cause you to lose Humanity (if it drops to 0, you become a cyberpsycho), the idea being that you're viewing yourself less as a person and more as a collection of different meat parts to swap out. If someone can't walk, they could get cyberlegs no problem, and it also specifically calls out gender-affirmation surgery as not costing any Humanity. You also lose Humanity for other traumas (eg witnessing a gruesome murder, living in poverty), and can recover what you've lost (though not all of what you've lost to cyberware specifically) through therapy. It is also now (don't think it was before) possible for a PC to come back from being a cyberpsycho.

2077 (the video game) has a whole series of missions where the idea is to take in "cyberpsychos" alive so that they can be treated.