Currently on season 2 and I had no idea there would be themes of alienation, nihilism, searching for meaning and belonging, and crumbling of the American dream, etc. I thought it was just a crime drama with some comedy involved. I'm pleasantly surprised and its making rediscover my gabagool side.
I've never seen The Wire but yes I think you should give it a try. A good blend of comedy, drama, and suspense.