If we’re being simulated, it’s a simulation that’s running on a subatomic granularity with a strict material causality all the way up to the macro world. To dispute this fact is to go against all of modern scientific consensus, the very idea of science itself.

Exactly! The inevitable conclusion of anyone with enough critical thinking and scientific rigour is that "If this is a simulation, it's operating on a level so advanced that it's functionally no different from reality, so for all intents and purposes I might as well treat it as such." Pascal's Wager, but for right now rather than some distant afterlife.