Between Jan 22, 2022, and March 12, 2022, we recruited 11 410 participants who were screened for eligibility, of whom 10 267 (99·8%) participants (5738 [55·9%] men, 4529 [44·1%] women; median age 53 years [18–92]) received the study drugs: 9847 (95·9%) participants in the open-label cohort to receive aerosolised Ad5-nCoV, and 420 (4·1%) in the immunogenicity subcohort (212 in the aerosolised Ad5-nCoV group and 208 in the inactivated vaccine group). Adverse reactions were reported by 1299 (13%) of 10 059 participants within 28 days after receiving the booster vaccination with aerosolised Ad5-nCoV, but most of the adverse reactions reported were mild to moderate in severity. Participants in the aerosolised Ad5-nCoV group had a significantly higher level of the neutralising antibodies against omicron BA.4/5 (GMT 107·7 [95% CI 88·8–130·7]) than did those in the inactivated vaccine group (17·2 [16·3–18·2]) at day 28.
I'm 100% expecting my Western shithole country to drop the ball on inhaled vaccines as "everyone is already immune after 10 infections", but at least China, India, and our boy Cuba are keeping hope alive with more development. If things go well, I can see myself visiting China or Cuba to get a series.
Oh man this is gonna drive the antivaxx cranks off the deep end
inb4 they start wearing masks in public to "protect themselves from the aerosolized vaccine"
Unironically I hope this happens, masking is hugely helpful in preventing airborne illness
I know someone who worked a side project to this (how aerosole is distributed). Quite happy that the results seem promising. He felt that his research wouldn't contribute to anything (that was before Covid).
"everyone is already immune after 10 infections"
And, just so I'm on the right page - Pretty much every study says you lose your immunity within 6 months of infection, right? Like we're not seeing immunity, we're just seeing rolling infections as people gradually lose their immunity and get infected again weeks or months later?
Oh, I agree. I just assume that a lot of developed countries will not focus on new vaccines and this will be the excuse. My expectation for our political leaders is very low.
You're right about waning immunity.
