RDR2 very much has an anti-industrialist, anti-capitalist narrative. The gang essentially lives in a commune, but they're mostly terrible people who kill and rob. One of the minor villains of the game is a loan shark who you do missions for, and it shows how much he preys on poor and downtrodden people, like a man with Tuberculosis and a widow whose husband died to working in a mine to pay off debts. Two of the game's main villains are a Pinkerton and a capitalist. You spend one chapter of the game in the deep south where the main grunt enemies are ex-Confederates and larpers. There's also a really weird chapter like the Mexico one, where you go off to a fictional Carribean island and help a bunch of sugar cane workers in their revolution and it ends with you blowing up a Cuban warship. So the themes are pretty anti-capitalist.