I would guess that the main thing that makes withdrawal from Cymbalta more hellish than Trintellix is the significant difference in half lives. Antidepressants with short half lives tend to be brutal to taper down and I would really recommend that everyone checks that aspect of a medication before deciding on it, especially if it's one of the first you're trying. For some reason I've known multiple people to be prescribed venlafaxine as an initial treatment by their PCPs, when it's notorious for a short half life and is difficult to discontinue. I don't know why this isn't given more consideration by doctors.