Not really, it's all about genetic sensitivity of the hair follicles to dihydrotestosterone (DHT), a testosterone byproduct. Hair follicles sensitive to DHT shrink and die. So you could have high testosterone, but if your hair follicles are not sensitive to DHT, you'll experience less balding. Meanwhile you could have low testosterone, but if your hair follicles are sensitive to DHT, you'll experience more rapid balding.
Finasteride works by blocking and drastically decreasing the production of DHT, which is also why some men experience extreme side effects while taking oral finasteride. There are topical finasteride creams you can get to try reduce the systemic effects of the drug by only applying it to the scalp. So I guess if you could just lower sensitivity of the hair to DHT in the first place, it would be a much better solution.
You could, it's pretty easy to mess around with vectors in the post-crispr era, but uh, blocking those genes is gonna be more or less equivalent to going on Spironolactone or at least a very heavy Duasteride regimen. It's an uh exciting way to accomplish this. (If you know someone who tried doing this or got someone to help, No You Don't)
Don’t high T men bald a lot faster? I thought they hated that
Not really, it's all about genetic sensitivity of the hair follicles to dihydrotestosterone (DHT), a testosterone byproduct. Hair follicles sensitive to DHT shrink and die. So you could have high testosterone, but if your hair follicles are not sensitive to DHT, you'll experience less balding. Meanwhile you could have low testosterone, but if your hair follicles are sensitive to DHT, you'll experience more rapid balding.
I wonder if you could use a non-encoding vector to just toggle a couple genes and increase your DHT resistance
Finasteride works by blocking and drastically decreasing the production of DHT, which is also why some men experience extreme side effects while taking oral finasteride. There are topical finasteride creams you can get to try reduce the systemic effects of the drug by only applying it to the scalp. So I guess if you could just lower sensitivity of the hair to DHT in the first place, it would be a much better solution.
You could, it's pretty easy to mess around with vectors in the post-crispr era, but uh, blocking those genes is gonna be more or less equivalent to going on Spironolactone or at least a very heavy Duasteride regimen. It's an uh exciting way to accomplish this. (If you know someone who tried doing this or got someone to help, No You Don't)
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