I had a rough time being isolated for several months on end, especially near the end where I was possibly a hair away from a legitimate nervous breakdown. Even though things have been largely "back to normal" for me since mid-late April, I feel like the effects are still lingering and that I get anxious/depressed more easily than I did before.
I think I've gotten a little worse at talking to people/little more socially anxious. Background of my life's been colored by anxiety and depression for years though, so it's hard to say.