"Oh, you are asking me about an actual problem with my unrealistic plans to colonize Mars? I have no idea, but I must say we plan to colonize Mars soon in order to get money from the stupid investors, lmao"
https://twitter.com/marinakoren/status/1461114697713954820
The science suggests that embryonic development needs gravity
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Just wear a girdle then?
Gravity on Mars is not that much lower than on Earth.
It's 30% of Earth's gravity. Astronauts would need to exercise frequently and intensely to not lose muscle and bone mass. People born on Mars would be unable to return to Earth as their vascular systems would be too weak to function in gravity that's 3x stronger than they've grown up in.
up the OPA
I assume that, at a certain point, residency on Mars would be functionally permanent. For the same reason we're not having a conversation about colonizing Jupiter, we wouldn't be speculating about sending people back from Mars to Earth.
Past that - and assuming you could solve the umpteen zillion other problems associated with permanent residency on a foreign planet - this would be one of the most radical experiments in speciation since domestication began. I have to assume that the first generation on Mars would have an atrocious mortality rate. But subsequent generations would adapt, just as they have adapted on Earth for the last two billion years.
(37.5% of Earth gravity but everything else @fox said still applies)