New data released by the Productivity Commission in January shows that up to June 30, 22,297 Aboriginal and Torres Strait Islander children were living away from their parents.
Chair of SNAICC, the peak body for Indigenous youth advocacy, Muriel Bamblett, said more Indigenous children are entering out-of-home care than ever before.
This year also marks 25 years of the Bringing Them Home report, which unveiled the trauma and injustice of the Stolen Generations.
In NSW alone, more than 40 per cent of children in out-of-home care are Indigenous.
"This is a national crisis," said John Leha, chief executive of NSW Child, Family and Community Peak Aboriginal Corporation (AbSec).
"The statistics these days are 11 times more, in terms of the amount of children being removed from their family since the actual national apology."