This has been known for more than a decade (this study is just a review of existing research), and is not directly related to the efficacy of SSRIs (although the serotonin "theory" might have led to their adoption, idk).
For a while now, as I understand it, the view has been that SSRIs cause the downregulation (decreased new production of) serotonin receptors in reaction to the excess serotonin buildup they cause in the synapses (this is why they take a few weeks to kick in, despite increasing serotonin levels almost immediately, and is also why they will desensitive you to psychedelics like LSD, which act primarily on serotonin receptors). They decrease overall serotonin signalling, which in turn has downstream effects that alter certain activites of certain regions of the brain that are implicated in depression. (This is based mostly on discussions I had with my psychiatrist a few months ago, so if there are any actual experts here, correct me if I'm wrong.)
That being said, SSRIs suck ass, their side effects are awful, and I think it's medical malpractice to make them a first-line treatment tbh. It's really mind-boggling that they're the go-to given how much shit they fuck up.
That being said, SSRIs suck ass, their side effects are awful, and I think it’s medical malpractice to make them a first-line treatment tbh
I love reading about their effects on libido including doctors "joking" to women about how they won't need birth control anymore (due to lack of desire for sex) and such side effects can last years after discontinuation very cool definitely not fucked up
This is just one anecdote, but for me starting an SSRI was incredible. The start up period was rough, but once I got used to it I had almost no side effects and my panic attacks went from weekly to annual. I understand that this isn't everyone's experience though.
I don't doubt it. They do sometimes work, which is why I don't like the way this paper is being passed around; people are drawing incorrect conclusions from it.
That being said, here's my anecdote: I was worried about the side effects and hesistant to try them, but everyone dismissed my concerns, insisting that SSRIs are the "gold standard", that they're the most effective, that the side effects usually aren't too severe, blah blah blah. But not only did everything I worried about happening happen, they also did absolutely nothing to help me. I would rather have wasted my time with bupropion or some other drug that didn't fuck my shit up at all. Drugs with less severe and less frequent side effects should be tried first (that's usually the standard in medicine!). I believe the pharmaceutical industry has had a hand in this, and I think it constitutes systematic malpractice.
Yes. No. Maybe. Different people react differently to them. Lots of people tolerate them with no side effects, other people have terrible side effects. As far as I know there's no way to tell who will and who won't respond well to them, though I think there are now some genetic testing techniques that can help figure out which medications are more likely to work.
I dunno, I've been taking an SSRI for a while and they've worked pretty well for mellowing out my anxiety and depression. I am planning on stopping taking them eventually, especially when i go to get some ADHD meds.
This has been known for more than a decade (this study is just a review of existing research), and is not directly related to the efficacy of SSRIs (although the serotonin "theory" might have led to their adoption, idk).
For a while now, as I understand it, the view has been that SSRIs cause the downregulation (decreased new production of) serotonin receptors in reaction to the excess serotonin buildup they cause in the synapses (this is why they take a few weeks to kick in, despite increasing serotonin levels almost immediately, and is also why they will desensitive you to psychedelics like LSD, which act primarily on serotonin receptors). They decrease overall serotonin signalling, which in turn has downstream effects that alter certain activites of certain regions of the brain that are implicated in depression. (This is based mostly on discussions I had with my psychiatrist a few months ago, so if there are any actual experts here, correct me if I'm wrong.)
That being said, SSRIs suck ass, their side effects are awful, and I think it's medical malpractice to make them a first-line treatment tbh. It's really mind-boggling that they're the go-to given how much shit they fuck up.
I love reading about their effects on libido including doctors "joking" to women about how they won't need birth control anymore (due to lack of desire for sex) and such side effects can last years after discontinuation very cool definitely not fucked up
growing up in my 20's thinking i was ace but it was that or constantly wanting to redact myself, shoutout to ssri's i guess
My ex and I taking SSRIs ultimately led to our breakup. The libido thing is no joke.
My SO's libido has been fucked for like 6 years now. She took Zoloft for like, one year
My partner is on SSRIs, I don’t need :volcel-judge: :yea:
This is just one anecdote, but for me starting an SSRI was incredible. The start up period was rough, but once I got used to it I had almost no side effects and my panic attacks went from weekly to annual. I understand that this isn't everyone's experience though.
I don't doubt it. They do sometimes work, which is why I don't like the way this paper is being passed around; people are drawing incorrect conclusions from it.
That being said, here's my anecdote: I was worried about the side effects and hesistant to try them, but everyone dismissed my concerns, insisting that SSRIs are the "gold standard", that they're the most effective, that the side effects usually aren't too severe, blah blah blah. But not only did everything I worried about happening happen, they also did absolutely nothing to help me. I would rather have wasted my time with bupropion or some other drug that didn't fuck my shit up at all. Drugs with less severe and less frequent side effects should be tried first (that's usually the standard in medicine!). I believe the pharmaceutical industry has had a hand in this, and I think it constitutes systematic malpractice.
Do SSRI's like prozac actually fuck you if taken as a child?
Yes. No. Maybe. Different people react differently to them. Lots of people tolerate them with no side effects, other people have terrible side effects. As far as I know there's no way to tell who will and who won't respond well to them, though I think there are now some genetic testing techniques that can help figure out which medications are more likely to work.
I dunno, I've been taking an SSRI for a while and they've worked pretty well for mellowing out my anxiety and depression. I am planning on stopping taking them eventually, especially when i go to get some ADHD meds.