I think Janeway would make for a scarier enemy. Sisko tends to mostly follow the rules, so if I offer unconditional surrender, I'd probably survive. But with Janeway it's a coin flip.
Remember that time sisko poisoned an entire planet because he was really mad at one guy?
In fairness to Sisko in that situation, Eddington did go out of his way to personally piss off Sisko. That's not usually a winning strategy.
"To be fair to Sisko, Eddington should have known what an unhinged maniac he is before daring to fight fascism anywhere near him"
You could always feign having a derelict vessel (not hard with a Pakled chief engineer) and use that as a ruse in which you request aid from Sisko's vessel. He's enough of a goody-two-shoes to go along with it, although he's probably not going to take the bait as badly as Picard would. His away team has an "accident" involving an EPS conduit that has been rigged by your mumbling engineering genius first officer, and the injuries are treated by an emergency medical hologram whose grasp of medicine pretty much starts and stops with replicated leeches. You could probably take out one or two senior staff that way before they realize what's happening, provided you can get Morn to shut up while he's establishing the initial hail.
If Deanna Troi is your helm officer, you also have like +300% bonus damage on kamikaze maneuvers, so that's one to keep in the back pocket.
