Been reading it lately, and it helps reduce my scrolling time. I've hardly read any, so you can recommend really popular stuff, too.
I've read Vagabond, 20th Century Boys, Claymore (years ago), and some berserk. I just finished reading Teppu, which I thought was an interesting subversion of a lot of anime tropes. I also liked that it was a short run (only 8 volumes). I guess I like seinen, but I've also enjoyed josei like She Loves to Cook, and She Loves to Eat.
Anyway, no shonen please. Hard mode: please nothing about high school
seconded, BLAME! is a very thought provoking comic.
Definitely gonna check it out