I've taken shrooms a couple times recently (2g doses) with incredibly minimal effects. I know the shrooms are potent, two friends started tripping at half that dose. I know lamictal blocks dissociative states does that mean it blocks the ability to trip too?
If you ever feel inclined to, Stahl's psychopharmacology is a really good book for this.
It's dense and it will probably be challenging depending on your current level of knowledge of biology/psychology/chemistry but if there's one book that I could recommend for understanding the whole thing in a comprehensive way, it's this one.
Oh you're good! Yeah I know people on Lamictal that trip, although I've never heard of it reducing the intensity of trips. Are you on any other psych meds? Lamictal is really light and really shouldn't be much of a blocker
Yep there's your issue. It outcompetes shrooms and acid for seratonin action, kinda like how Naltrexone outcompetes opiates and alcohol for opiate action. Seratonin syndrome isn't really an issue with normal psychedelics like shrooms and acid, but I would avoid MDMA, Ayahuasca and DXM like the fucking plague
I would not be super concerned about Seratonin Syndrome with the mixture. To sum the link up, there are pretty much no serious adverse reactions from shrooms alone (the source of this in the article is Poison Control). Pretty much every case of serious seratonin syndrome can be attributed to
- excessive dosing
- stupid drug mixes (dxm&mdma, anything other than shrooms/dmt and weed with a MAOI inhibitor)
- having shit laced/be fake (fake tabs)
- police intervention (not making that one up)
There is pretty much no risk mixing any SRIs (SSRIs, SNRIs, Tryciclics) with shrooms or not insane doses of LSD, or even MDMA apparently (that one is new to me from this piece) If y'all wanna actually read the full thing, look it up on whatever Sci-hub mirror you prefer.
To sum it up, MAOIs in your body fight against seratonin toxcicity and break down seratonin. The way it's typically used is to prevent DMT breaking down in your body for oral consumption, but it prevents the breakdown of a lot of seratonin. This is completely fine when taking shrooms or DMT, will even make your trip way cooler with classic tryptamines that don't release seratonin, but anything that releases seratonin puts you at risk for seratonin syndrome. As someone that's gotten seratonin sydrome twice (once on accident from stupid drug mixes, once on purpose from a suicude attempt) people really overstate the risks of it
Phenylamines like the 2C family all have MAOI inhibition action, so you never want to take them with psych meds
