I've taken shrooms a couple times recently (2g doses) with incredibly minimal effects. I know the shrooms are potent, two friends started tripping at half that dose. I know lamictal blocks dissociative states does that mean it blocks the ability to trip too?
Bump for curiosity. From my googling there were a couple of anecdotal accounts of reduced efficacy of psychedelics on lamictal, but nothing substantive. What i gleaned from wikipedia the pharmacology of lamictal seems to operate on significantly different mechanisms from psychedelics (sodium channel blockage w lamictal vs seratonin receptor agonism).
From wikipedia:
Lamotrigine does not have pronounced effects on any of the usual neurotransmitter receptors that anticonvulsants affect (..., serotonin 5-HT2,...)
Of which Serotonin 5-HT2A receptors are a subclass - the receptors acted upon by psychedelics. So at the very least there doesnt seem to be a direct interaction in terms of receptors and youre probably not at risk of seratonin syndrome like you would be on SSRIs.
So thats all ive got - i wasnt able to find any abstracts on the topic with a quick google search. Hopefully a comrade with an actual background in pharmacology can shed some light on this!
Interesting, I think i'd have to do a lot of reading to really understand it.
If you ever feel inclined to, Stahl's psychopharmacology is a really good book for this.
It's dense and it will probably be challenging depending on your current level of knowledge of biology/psychology/chemistry but if there's one book that I could recommend for understanding the whole thing in a comprehensive way, it's this one.
There are sites that talk about antidepressants and their noted dulling of psychadelics (also prescribed by therapists) i learned that some types of uptake inhibitors can 'fill' the same receptors that the mushrooms use. Turned out my newly prescribed anti-depressant was listed as "most dulling" (which tracked with the reason i looked it up in the first place).
I also read that some interactions with a couple types drugs can actually be dangerous, overloading the brain with seratonin and even causing seizures. You should be careful and check it out friend, meanwhile I'll see if i can find that site again with your drug
edit: here is the site i remember, with helpful explanations of some interactions.
Looks like It was lithum i was referencing as possible OD. lamictal is not listed, sorry.
I can't really find anything official on lamotrazinec's effects but the shroom heads on Reddit and around the web i saw seem to experience dulling effects from it.
@LeylaLove@hexbear.net Sorry to call you out but you seem to be our resident expert. Any ideas?
Oh you're good! Yeah I know people on Lamictal that trip, although I've never heard of it reducing the intensity of trips. Are you on any other psych meds? Lamictal is really light and really shouldn't be much of a blocker
Yep there's your issue. It outcompetes shrooms and acid for seratonin action, kinda like how Naltrexone outcompetes opiates and alcohol for opiate action. Seratonin syndrome isn't really an issue with normal psychedelics like shrooms and acid, but I would avoid MDMA, Ayahuasca and DXM like the fucking plague
venlafaxine
Oooh yeah theres yer problem, thats an SNRI. Thats going to directly interact with the same receptors shrooms work on. You're going to get reduced effects and you'll need to be careful of seratonin syndrome
I would not be super concerned about Seratonin Syndrome with the mixture. To sum the link up, there are pretty much no serious adverse reactions from shrooms alone (the source of this in the article is Poison Control). Pretty much every case of serious seratonin syndrome can be attributed to
- excessive dosing
- stupid drug mixes (dxm&mdma, anything other than shrooms/dmt and weed with a MAOI inhibitor)
- having shit laced/be fake (fake tabs)
- police intervention (not making that one up)
There is pretty much no risk mixing any SRIs (SSRIs, SNRIs, Tryciclics) with shrooms or not insane doses of LSD, or even MDMA apparently (that one is new to me from this piece) If y'all wanna actually read the full thing, look it up on whatever Sci-hub mirror you prefer.
Interesting, GOOD post! Thankz 4 the info comrade Leyla
I'm not familiar with MAOI inhibitors. What is their pharmacology and what makes them so dangerous to take with anything besides shrooms/dmt/weed?To sum it up, MAOIs in your body fight against seratonin toxcicity and break down seratonin. The way it's typically used is to prevent DMT breaking down in your body for oral consumption, but it prevents the breakdown of a lot of seratonin. This is completely fine when taking shrooms or DMT, will even make your trip way cooler with classic tryptamines that don't release seratonin, but anything that releases seratonin puts you at risk for seratonin syndrome. As someone that's gotten seratonin sydrome twice (once on accident from stupid drug mixes, once on purpose from a suicude attempt) people really overstate the risks of it
Phenylamines like the 2C family all have MAOI inhibition action, so you never want to take them with psych meds
Ohhh i see! Thats really good to know, thank you. Does that include mescaline as well or just the synthetic 2C-X derivatives?
Mescaline doesn't seem to have any interaction with psychiatric meds, that is as exception. However, there are a lot less studies on mescaline because even with San Pedros it's a fairly difficult process making it. 2C derivatives are 100 percent a no go though, they release seratonin and have MAOI properties, I wouldn't even mix a MAOI with ibuprofen personally, when I say that's all you can mix with it, I mean that as seriously as possible. I cannot repeat it enough, do not mix MAOIs with anything they're not intended to be mixed with
CW: Suicide
You don't have to really worry about Seratonin Syndrome unless you're taking something with an MAOI, or taking multiple SRIs at the same time (for example, taking Zoloft with DXM at high doses). Also to anybody who may be suicidal, mixing SRIs takes multiple days to kill, it will not be a quick and painless death. You can technically die off DXM (SNRI) and SSRIs, but you'll have to sit there thinking about it for days before you die, an absolutely (common) terrible suicide method, and you have to take a fat fucking dose of both.
Seriously, just take normal doses of classic psychedelics (shrooms, acid, MDMA, mescaline, ect.) and you'll be fine. Just don't start experimenting with other psychs, basic tryptamines and (real) acid have a GREAT safety profile. As long as you're not taking Lithium, you're fine on pretty much all psychiatric meds with classic psychedelics.
Whew, between that and the unspeakable horrors 2C derivatives are really nothing to fuck around with lightly. I'll tread carefully. Maybe one day I'll dip my toes into phenythylamines one day, but for now I think I'll just stick to the classics and read Shulgin to satisfy my curiosity. Thanks!
