While they’re all awful, the third one I think is the most concerning since we’re seeing the light at the end of the tunnel otherwise with vaccine. I have heard that the spread claims for the UK variant are hypotheses that haven’t really been properly tested (how can you?) and that the spread can be explained by poor pandemic responses as well.

That there are so many strains being identified now makes me think there is a real possibility of vaccine escape occurring, particular as these pressures become more common- i.e. in immunized populations.