Depends on how strong their short position is and how high GME shares are memed, but I seriously doubt these firms will suffer too badly. They'll have highly diversified investments and will be well prepared for recovery from bad trades. House always wins, especially when the house in question is one of the money printers for the bourgeoisie.

Edit: don't get me wrong though I'd love to watch these cunts go under at the hands of some wsb memes