I've got one on Tuesday that looks like my best shot at a new job since I got laid off in the summer. It's with a vice president of the company and the person whose position I'm filling since she got promoted
I'm just a little weirdo, I don't know how to make them want to hire me 
Be prepared to answer/create stories on the spot about experiences at work. Common questions in interviews are "Tell me about a time you [did something that shows how you react to various work situations]"
Questions along those longs will probably pop up
Why sir, I'm shitting as we speak
Just a bit of personal experience, I always get thrown for a loop by these questions and invariably answer with some variety of "this doesn't quite fit what you're asking about, but [story about something somewhat similar]" or "i dont think ive ever been in that position" and sometimes that second one gets the addendum "and that's because im built different and avoid that problem by [some more cautious approach]"
and I must be a pretty good interview guy because these motherfuckers always love me by the end of the process, so as with most things in the interview, i dont think it really matters whether or not you have something applicable to say in response, all that matters is that you can maintain the flow of the conversation in a way that doesn't feel jarring. cause interviews are dumb bullshit and the only objective is to not look like a weirdo, an asshole, or someone incapable of working
Ya you seem great at these. The most important thing is to say anything if you can't come up with a direct answer
Under absolutely no circumstances is it a good idea to say "I've never had this situation come up before"
Things of note:
Keep the anecdotes snappy and to the point, try not to start drifting or rambling.
Don't use anecdotes where you don't look good by the end of the anecdote... which is what can happen when 1) starts to happen. ( I might have had an interview where I got a bit too relaxed with the interviewer and I might have done this once.)