Oh yeah, I'm in complete agreement there. A brain reset is a good way to phrase it. It's like a clearing away, a decluttering.

Speaking for myself at least, I have no doubt that the experience plays a big role in the lasting antidepressant effects. A good trip (and pretty much all of them are) is intellectually stimulating and emotionally freeing. There's some question about whether other arylcyclohexalamines can have the same antidepressant properties, but of those I've tried, they usually do for me.