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Oh and I definitely dont’t think it’s safe long term. Some of the side effects are bladder cancer, bone density issues and heart failure.
Pio seems to interact with mesenchymal stem cells and a study (though not done on humans) showed transdifferentation of bone marrow mesenchymal stem cells into adipose cells IIRC. Mesenchymal stem cells also act as the prescursor to many other cells such as muscle and cartilage cells, so it’s probably not too good to affect those too much😅